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TitleA natural DYRK1A inhibitor as a potential stimulator for beta-cell proliferation in diabetes.
Journal, issue, pagesClin Transl Med, Vol. 11, Page e494-e494, Year 2021
Publish dateDec 28, 2019 (structure data deposition date)
AuthorsZheng, M. / Zhang, Q. / Zhang, C. / Wu, C. / Yang, K. / Song, Z. / Wang, Q. / Li, C. / Zhou, Y. / Chen, J. ...Zheng, M. / Zhang, Q. / Zhang, C. / Wu, C. / Yang, K. / Song, Z. / Wang, Q. / Li, C. / Zhou, Y. / Chen, J. / Li, H. / Chen, L.
External linksClin Transl Med / PubMed:34323401
MethodsX-ray diffraction
Resolution2.699 Å
Structure data

PDB-6ln1:
A natural inhibitor of DYRK1A for treatment of diabetes mellitus
Method: X-RAY DIFFRACTION / Resolution: 2.699 Å

Chemicals

ChemComp-EKU:
1,3,5,8-tetrakis(oxidanyl)xanthen-9-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / anti-diabetic activity / Desmethylbellidifolin / DYRK1A / inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex

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