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-Structure paper
Title | Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent |
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Journal, issue, pages | Mol Cancer Ther, Vol. 20, Page 1846-1857, Year 2021 |
Publish date | Dec 16, 2022 (structure data deposition date) |
Authors | Jernigan, F. / Branstrom, A. / Baird, J.D. / Cao, L. / Dali, M. / Furia, B. / Kim, M.J. / O'Keefe, K. / Kong, R. / Laskin, O.L. ...Jernigan, F. / Branstrom, A. / Baird, J.D. / Cao, L. / Dali, M. / Furia, B. / Kim, M.J. / O'Keefe, K. / Kong, R. / Laskin, O.L. / Colacino, J.M. / Pykett, M. / Mollin, A. / Sheedy, J. / Dumble, M. / Moon, Y.-C. / Sheridan, R. / Muehlethaler, T. / Spiegel, R.J. / Prota, A.E. / Steinmetz, M.O. / Weetall, M. |
External links | Mol Cancer Ther / PubMed:34315764 |
Methods | X-ray diffraction |
Resolution | 2.1005 Å |
Structure data | PDB-8c0f: |
Chemicals | ChemComp-GTP: ChemComp-MG: ChemComp-CA: ChemComp-GDP: ChemComp-MES: ChemComp-GOL: ChemComp-SOZ: ChemComp-EDO: ChemComp-IMD: ChemComp-ACP: ChemComp-HOH: |
Source |
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Keywords | CELL CYCLE / TUBULIN FOLD / CYTOSKELETON / MICROTUBULE |