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-Structure paper
タイトル | High-Resolution Imaging of Human Viruses in Liquid Droplets. |
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ジャーナル・号・ページ | Adv Mater, Vol. 33, Issue 37, Page e2103221, Year 2021 |
掲載日 | 2021年7月24日 |
著者 | G M Jonaid / William J Dearnaley / Michael A Casasanta / Liam Kaylor / Samantha Berry / Madeline J Dukes / Michael S Spilman / Jennifer L Gray / Deborah F Kelly / |
PubMed 要旨 | Liquid-phase electron microscopy (LP-EM) is an exciting new area in the materials imaging field, providing unprecedented views of molecular processes. Time-resolved insights from LP-EM studies are a ...Liquid-phase electron microscopy (LP-EM) is an exciting new area in the materials imaging field, providing unprecedented views of molecular processes. Time-resolved insights from LP-EM studies are a strong complement to the remarkable results achievable with other high-resolution techniques. Here, the opportunities to expand LP-EM technology beyond 2D temporal assessments and into the 3D regime are described. The results show new structures and dynamic insights of human viruses contained in minute volumes of liquid while acquired in a rapid timeframe. To develop this strategy, adeno-associated virus (AAV) is used as a model system. AAV is a well-known gene therapy vehicle with current applications involving drug delivery and vaccine development for COVID-19. Improving the understanding of the physical properties of biological entities in a liquid state, as maintained in the human body, has broad societal implications for human health and disease. |
リンク | Adv Mater / PubMed:34302401 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 5.0 Å |
構造データ | EMDB-23634: AAV3 in liquid phase |