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Title3 H -Pyrazolo[4,3- f ]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.
Journal, issue, pagesJ. Med. Chem., Vol. 64, Page 10981-10996, Year 2021
Publish dateDec 11, 2020 (structure data deposition date)
AuthorsDayal, N. / Reznickova, E. / Hernandez, D.E. / Perina, M. / Torregrosa-Allen, S. / Elzey, B.D. / Skerlova, J. / Ajani, H. / Djukic, S. / Vojackova, V. ...Dayal, N. / Reznickova, E. / Hernandez, D.E. / Perina, M. / Torregrosa-Allen, S. / Elzey, B.D. / Skerlova, J. / Ajani, H. / Djukic, S. / Vojackova, V. / Lepsik, M. / Rezacova, P. / Krystof, V. / Jorda, R. / Sintim, H.O.
External linksJ. Med. Chem. / PubMed:34288692
MethodsX-ray diffraction
Resolution2.54 Å
Structure data

PDB-7b7s:
CDK2/cyclin A2 in complex with 3H-pyrazolo[4,3-f]quinoline-based derivative HSD1368
Method: X-RAY DIFFRACTION / Resolution: 2.54 Å

Chemicals

ChemComp-T1T:
7-(3-(trifluoromethyl)-1H-pyrazol-4yl)-3,8,10,11-tetrahydropyrazolo[4,3-f]thiopyrano[3,4-c]quinoline 9-oxide

ChemComp-NO3:
NITRATE ION

ChemComp-SO4:
SULFATE ION

ChemComp-SGM:
MONOTHIOGLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / cyclin-dependent kinase / FLT3 / acute myeloid leukemia / inhibition

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