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TitleSelf-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
Journal, issue, pagesJ. Med. Chem., Vol. 64, Page 11267-11287, Year 2021
Publish dateMar 17, 2021 (structure data deposition date)
AuthorsLi, L. / Chenna, B.C. / Yang, K.S. / Cole, T.R. / Goodall, Z.T. / Giardini, M. / Moghadamchargari, Z. / Hernandez, E.A. / Gomez, J. / Calvet, C.M. ...Li, L. / Chenna, B.C. / Yang, K.S. / Cole, T.R. / Goodall, Z.T. / Giardini, M. / Moghadamchargari, Z. / Hernandez, E.A. / Gomez, J. / Calvet, C.M. / Bernatchez, J.A. / Mellott, D.M. / Zhu, J. / Rademacher, A. / Thomas, D. / Blankenship, L.R. / Drelich, A. / Laganowsky, A. / Tseng, C.K. / Liu, W.R. / Wand, A.J. / Cruz-Reyes, J. / Siqueira-Neto, J.L. / Meek, T.D.
External linksJ. Med. Chem. / PubMed:34288674
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-7m2p:
Structure of the SARS-CoV-2 3CL protease in complex with inhibitor 18
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • severe acute respiratory syndrome coronavirus 2
  • synthetic construct (others)
KeywordsViral protein/hydrolase inhibitor / COVID-19 / SARS-CoV-2 / 3CL protease / aldehyde inhibitor / Viral protein-hydrolase inhibitor complex

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