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TitleStrictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.
Journal, issue, pagesSci Rep, Vol. 11, Page 14532-14532, Year 2021
Publish dateJun 16, 2021 (structure data deposition date)
AuthorsSuzuki, A. / Kunugi, A. / Tajima, Y. / Suzuki, N. / Suzuki, M. / Toyofuku, M. / Kuno, H. / Sogabe, S. / Kosugi, Y. / Awasaki, Y. ...Suzuki, A. / Kunugi, A. / Tajima, Y. / Suzuki, N. / Suzuki, M. / Toyofuku, M. / Kuno, H. / Sogabe, S. / Kosugi, Y. / Awasaki, Y. / Kaku, T. / Kimura, H.
External linksSci Rep / PubMed:34267258
MethodsX-ray diffraction
Resolution1.44 Å
Structure data

PDB-7f3o:
Crystal structure of the GluA2o LBD in complex with glutamate and TAK-653
Method: X-RAY DIFFRACTION / Resolution: 1.44 Å

Chemicals

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-0YK:
7-(4-cyclohexyloxyphenyl)-9-methyl-4$l^{6}-thia-1$l^{4},5,8-triazabicyclo[4.4.0]deca-1(10),6,8-triene 4,4-dioxide

ChemComp-ZN:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / AMPA RECEPTOR LIGAND-BINDING DOMAIN / ALLOSTERIC MODULATION COMPLEX / MEMBRANE PROTEIN

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