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-Structure paper
Title | Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 10711-10741, Year 2021 |
Publish date | May 2, 2021 (structure data deposition date) |
Authors | Lucas, S.C.C. / Atkinson, S.J. / Chung, C.W. / Davis, R. / Gordon, L. / Grandi, P. / Gray, J.J.R. / Grimes, T. / Phillipou, A. / Preston, A.G. ...Lucas, S.C.C. / Atkinson, S.J. / Chung, C.W. / Davis, R. / Gordon, L. / Grandi, P. / Gray, J.J.R. / Grimes, T. / Phillipou, A. / Preston, A.G. / Prinjha, R.K. / Rioja, I. / Taylor, S. / Tomkinson, N.C.O. / Wall, I. / Watson, R.J. / Woolven, J. / Demont, E.H. |
External links | J. Med. Chem. / PubMed:34260229 |
Methods | X-ray diffraction |
Resolution | 1.301 - 1.602 Å |
Structure data | PDB-7oe8: PDB-7oe9: |
Chemicals | ChemComp-EDO: ChemComp-V9Q: ChemComp-HOH: ChemComp-V9N: |
Source |
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Keywords | NUCLEAR PROTEIN / Inhibitor / Bromodomain |