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Structure paper

TitleHBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
Journal, issue, pagesNucleic Acids Res., Vol. 49, Page 8037-8059, Year 2021
Publish dateSep 11, 2020 (structure data deposition date)
AuthorsXiao, Y. / Li, W. / Yang, H. / Pan, L. / Zhang, L. / Lu, L. / Chen, J. / Wei, W. / Ye, J. / Li, J. ...Xiao, Y. / Li, W. / Yang, H. / Pan, L. / Zhang, L. / Lu, L. / Chen, J. / Wei, W. / Ye, J. / Li, J. / Li, G. / Zhang, Y. / Tan, M. / Ding, J. / Wong, J.
External linksNucleic Acids Res. / PubMed:34259319
MethodsX-ray diffraction
Resolution1.8 - 2.51 Å
Structure data

PDB-7d0o:
Crystal structure of human HBO1-BRPF2 in apo form
Method: X-RAY DIFFRACTION / Resolution: 2.51 Å

PDB-7d0p:
Crystal structure of human HBO1-BRPF2 in complex with propionyl-coenzyme A
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7d0q:
Crystal structure of human HBO1-BRPF2 in complex with butyryl-coenzyme A
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

PDB-7d0r:
Crystal structure of human HBO1-BRPF2 in complex with crotonoyl-coenzyme A
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-7d0s:
Crystal structure of human HBO1-BRPF2 in complex with succinyl-coenzyme A
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-1VU:
propionyl Coenzyme A

ChemComp-CL:
Unknown entry

ChemComp-BCO:
Butyryl Coenzyme A

ChemComp-COO:
CROTONYL COENZYME A

ChemComp-SCA:
SUCCINYL-COENZYME A

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / histone acetyltransferase / complex / HBO1 / BRPF2 / propionyl-CoA / acylation / butyryl-CoA / crotonoyl-CoA / succinyl-CoA

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