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Title | GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 11841-11856, Year 2021 |
Publish date | May 10, 2021 (structure data deposition date) |
Authors | Liang, J. / Zbieg, J.R. / Blake, R.A. / Chang, J.H. / Daly, S. / DiPasquale, A.G. / Friedman, L.S. / Gelzleichter, T. / Gill, M. / Giltnane, J.M. ...Liang, J. / Zbieg, J.R. / Blake, R.A. / Chang, J.H. / Daly, S. / DiPasquale, A.G. / Friedman, L.S. / Gelzleichter, T. / Gill, M. / Giltnane, J.M. / Goodacre, S. / Guan, J. / Hartman, S.J. / Ingalla, E.R. / Kategaya, L. / Kiefer, J.R. / Kleinheinz, T. / Labadie, S.S. / Lai, T. / Li, J. / Liao, J. / Liu, Z. / Mody, V. / McLean, N. / Metcalfe, C. / Nannini, M.A. / Oeh, J. / O'Rourke, M.G. / Ortwine, D.F. / Ran, Y. / Ray, N.C. / Roussel, F. / Sambrone, A. / Sampath, D. / Schutt, L.K. / Vinogradova, M. / Wai, J. / Wang, T. / Wertz, I.E. / White, J.R. / Yeap, S.K. / Young, A. / Zhang, B. / Zheng, X. / Zhou, W. / Zhong, Y. / Wang, X. |
External links | J. Med. Chem. / PubMed:34251202 |
Methods | X-ray diffraction |
Resolution | 2.24 Å |
Structure data | PDB-7msa: |
Chemicals | ChemComp-G9J: ChemComp-ZNM: ChemComp-HOH: |
Source |
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Keywords | TRANSCRIPTION / antagonist / breast cancer |