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Structure paper

TitleStructural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.
Journal, issue, pagesNat Commun, Vol. 12, Page 4226-4226, Year 2021
Publish dateSep 1, 2020 (structure data deposition date)
AuthorsXu, K. / Wang, Y. / Shen, C.H. / Chen, Y. / Zhang, B. / Liu, K. / Tsybovsky, Y. / Wang, S. / Farney, S.K. / Gorman, J. ...Xu, K. / Wang, Y. / Shen, C.H. / Chen, Y. / Zhang, B. / Liu, K. / Tsybovsky, Y. / Wang, S. / Farney, S.K. / Gorman, J. / Stephens, T. / Verardi, R. / Yang, Y. / Zhou, T. / Chuang, G.Y. / Lanzavecchia, A. / Piccoli, L. / Kwong, P.D.
External linksNat Commun / PubMed:34244481
MethodsX-ray diffraction
Resolution2.457 - 3.37 Å
Structure data

PDB-7jz1:
Crystal structure of broadly Plasmodium RIFIN reactive LAIR1-inserted antibody MGC34
Method: X-RAY DIFFRACTION / Resolution: 3.37 Å

PDB-7jz4:
Crystal structure of broadly Plasmodium RIFIN reactive LAIR1-inserted antibody MGD21
Method: X-RAY DIFFRACTION / Resolution: 2.747 Å

PDB-7jzi:
Crystal structure of LAIR1 ectodomain (from MGD21) in complex with Plasmodium RIFIN (PF3D7_1040300) V2 domain
Method: X-RAY DIFFRACTION / Resolution: 2.707 Å

PDB-7jzk:
Crystal structure of LAIR1 ectodomain (from MGD21) in complex with Plasmodium RIFIN (PF3D7_0401300) V2 domain
Method: X-RAY DIFFRACTION / Resolution: 2.457 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-PT:
Unknown entry

Source
  • homo sapiens (human)
  • plasmodium falciparum (isolate nf54) (eukaryote)
KeywordsIMMUNE SYSTEM / LAIR1 / insertion / antibody / RIFIN / Malaria / Plasmodium

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