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TitleEnhanced Ability of Plant-Derived PGT121 Glycovariants To Eliminate HIV-1-Infected Cells.
Journal, issue, pagesJ. Virol., Vol. 95, Page e0079621-e0079621, Year 2021
Publish dateFeb 11, 2020 (structure data deposition date)
AuthorsAnand, S.P. / Ding, S. / Tolbert, W.D. / Prevost, J. / Richard, J. / Gil, H.M. / Gendron-Lepage, G. / Cheung, W.F. / Wang, H. / Pastora, R. ...Anand, S.P. / Ding, S. / Tolbert, W.D. / Prevost, J. / Richard, J. / Gil, H.M. / Gendron-Lepage, G. / Cheung, W.F. / Wang, H. / Pastora, R. / Saxena, H. / Wakarchuk, W. / Medjahed, H. / Wines, B.D. / Hogarth, M. / Shaw, G.M. / Martin, M.A. / Burton, D.R. / Hangartner, L. / Evans, D.T. / Pazgier, M. / Cossar, D. / McLean, M.D. / Finzi, A.
External linksJ. Virol. / PubMed:34232070
MethodsX-ray diffraction
Resolution2.1 - 2.6 Å
Structure data

PDB-6vsl:
Crystal structure of a human fucosylated IgG1 Fc expressed in tobacco plants (Nicotiana benthamiana)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-6vsz:
Crystal structure of a human afucosylated IgG1 Fc expressed in tobacco plants (Nicotiana benthamiana)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / immunoglobulin / crystallizable fragment / IgG1 / Fc

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