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TitleBinding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex.
Journal, issue, pagesNat Commun, Vol. 12, Page 4061-4061, Year 2021
Publish dateJun 25, 2020 (structure data deposition date)
AuthorsHuang, X. / Hu, H. / Webster, A. / Zou, F. / Du, J. / Patel, D.J. / Sachidanandam, R. / Toth, K.F. / Aravin, A.A. / Li, S.
External linksNat Commun / PubMed:34210982
MethodsX-ray diffraction
Resolution2.1 - 2.704 Å
Structure data

PDB-7cfb:
Drosophila melanogaster Krimper eTud1 apo structure
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-7cfc:
Drosophila melanogaster Krimper eTud1-Ago3 complex
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-7cfd:
Drosophila melanogaster Krimper eTud2-AubR15me2 complex
Method: X-RAY DIFFRACTION / Resolution: 2.704 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • drosophila melanogaster (fruit fly)
KeywordsGENE REGULATION / piRNA ampilication / gene silencing

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