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-Structure paper
Title | Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 118, Year 2021 |
Publish date | Sep 4, 2020 (structure data deposition date) |
Authors | Dampalla, C.S. / Zheng, J. / Perera, K.D. / Wong, L.R. / Meyerholz, D.K. / Nguyen, H.N. / Kashipathy, M.M. / Battaile, K.P. / Lovell, S. / Kim, Y. ...Dampalla, C.S. / Zheng, J. / Perera, K.D. / Wong, L.R. / Meyerholz, D.K. / Nguyen, H.N. / Kashipathy, M.M. / Battaile, K.P. / Lovell, S. / Kim, Y. / Perlman, S. / Groutas, W.C. / Chang, K.O. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:34210738 |
Methods | X-ray diffraction |
Resolution | 1.65 - 1.9 Å |
Structure data | PDB-7k0e: PDB-7k0f: PDB-7k0g: PDB-7k0h: |
Chemicals | ChemComp-K36: ChemComp-PG4: ChemComp-HOH: ChemComp-VR4: ChemComp-B1S: ChemComp-CL: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / COVID-19 / PROTEASE / severe acute respiratory syndrome coronavirus 2 / SARS-CoV-2 3CL protease Inhhibitors / hydrolase / deuterated hydrolase inhibitor / Hydrolase-Hydrolase Inhibitor complex / severe acute respiratory syndrome coronavirus / SARS 3CL protease Inhhibitors |