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TitleDiscovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.
Journal, issue, pagesJ. Med. Chem., Vol. 64, Page 10333-10349, Year 2021
Publish dateMar 22, 2021 (structure data deposition date)
AuthorsZhang, M. / Aguilar, A. / Xu, S. / Huang, L. / Chinnaswamy, K. / Sleger, T. / Wang, B. / Gross, S. / Nicolay, B.N. / Ronseaux, S. ...Zhang, M. / Aguilar, A. / Xu, S. / Huang, L. / Chinnaswamy, K. / Sleger, T. / Wang, B. / Gross, S. / Nicolay, B.N. / Ronseaux, S. / Harvey, K. / Wang, Y. / McEachern, D. / Kirchhoff, P.D. / Liu, Z. / Stuckey, J. / Tron, A.E. / Liu, T. / Wang, S.
External linksJ. Med. Chem. / PubMed:34196551
MethodsX-ray diffraction
Resolution2.74 Å
Structure data

PDB-7m4t:
Menin bound to M-1121
Method: X-RAY DIFFRACTION / Resolution: 2.74 Å

Chemicals

ChemComp-YQV:
methyl {(1S,2R)-2-[(1S)-2-(azetidin-1-yl)-1-(3-fluorophenyl)-1-{1-[(3-methoxy-1-{4-[(1S,4S)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptane-2-sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}ethyl]cyclopentyl}carbamate

ChemComp-7PR:
praseodymium triacetate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Inhibitor

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