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TitleTarget identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library.
Journal, issue, pagesCell Chem Biol, Vol. 28, Page 1602-1615.e9, Year 2021
Publish dateMay 30, 2020 (structure data deposition date)
AuthorsEmery, A. / Hardwick, B.S. / Crooks, A.T. / Milech, N. / Watt, P.M. / Mithra, C. / Kumar, V. / Giridharan, S. / Sadasivam, G. / Mathivanan, S. ...Emery, A. / Hardwick, B.S. / Crooks, A.T. / Milech, N. / Watt, P.M. / Mithra, C. / Kumar, V. / Giridharan, S. / Sadasivam, G. / Mathivanan, S. / Sudhakar, S. / Bairy, S. / Bharatham, K. / Hurakadli, M.A. / Prasad, T.K. / Kamariah, N. / Muellner, M. / Coelho, M. / Torrance, C.J. / McKenzie, G.J. / Venkitaraman, A.R.
External linksCell Chem Biol / PubMed:34111400
MethodsX-ray diffraction
Resolution3.16 Å
Structure data

PDB-7c8e:
Crystal Structure of 14-3-3 epsilon with 9J10 peptide
Method: X-RAY DIFFRACTION / Resolution: 3.16 Å

Chemicals

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • streptomyces avermitilis ma-4680 = nbrc 14893 (bacteria)
KeywordsPROTEIN BINDING / Signaling protein / Phosphopeptide binding / peptide complex

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