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TitleNOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.
Journal, issue, pagesCell Rep Med, Vol. 2, Page 100279-100279, Year 2021
Publish dateJul 16, 2020 (structure data deposition date)
AuthorsGeles, K.G. / Gao, Y. / Giannakou, A. / Sridharan, L. / Yamin, T.T. / Zhang, J. / Karim, R. / Bard, J. / Piche-Nicholas, N. / Charati, M. ...Geles, K.G. / Gao, Y. / Giannakou, A. / Sridharan, L. / Yamin, T.T. / Zhang, J. / Karim, R. / Bard, J. / Piche-Nicholas, N. / Charati, M. / Maderna, A. / Lucas, J. / Golas, J. / Guffroy, M. / Pirie-Shepherd, S. / Roy, M. / Qian, J. / Franks, T. / Zhong, W. / O'Donnell, C.J. / Tchistiakova, L. / Gerber, H.P. / Sapra, P.
External linksCell Rep Med / PubMed:34095881
MethodsX-ray diffraction
Resolution2.98 Å
Structure data

PDB-6xsw:
Structure of the Notch3 NRR in complex with an antibody Fab Fragment
Method: X-RAY DIFFRACTION / Resolution: 2.98 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/Immune System / Notch3 / Antibody / SIGNALING PROTEIN / SIGNALING PROTEIN-Immune System complex

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