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Structure paper

TitleHuman MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.
Journal, issue, pagesNucleic Acids Res., Vol. 49, Page 11629-11642, Year 2021
Publish dateDec 21, 2020 (structure data deposition date)
AuthorsYu, D. / Horton, J.R. / Yang, J. / Hajian, T. / Vedadi, M. / Sagum, C.A. / Bedford, M.T. / Blumenthal, R.M. / Zhang, X. / Cheng, X.
External linksNucleic Acids Res. / PubMed:34086966
MethodsX-ray diffraction
Resolution1.79 Å
Structure data

PDB-7l4x:
YTH Domain of Human YTHDC1 with dsDNA Comprising Single N6mA joined by two six-bp DNA duplexes in P3221 Crystal
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-7l4y:
YTH Domain of Human YTHDC1 with dsDNA Comprising Single N6mA joined by Two Six-bp DNA Duplexes in P212121 Crystal
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsDNA BINDING PROTEIN/DNA / N6-METHYLADENINE BINDING PROTEIN DOMAIN / SSDNA / DNA BINDING PROTEIN / PROTEIN-DNA COMPLEX / DNA BINDING PROTEIN-DNA complex

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