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TitleCtf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore.
Journal, issue, pagesJ Cell Biol, Vol. 220, Issue 8, Year 2021
Publish dateAug 2, 2021
AuthorsYun Quan / Stephen M Hinshaw / Pang-Che Wang / Stephen C Harrison / Huilin Zhou /
PubMed AbstractThe step-by-step process of chromosome segregation defines the stages of the cell cycle. In eukaryotes, signals controlling these steps converge upon the kinetochore, a multiprotein assembly that ...The step-by-step process of chromosome segregation defines the stages of the cell cycle. In eukaryotes, signals controlling these steps converge upon the kinetochore, a multiprotein assembly that connects spindle microtubules to chromosomal centromeres. Kinetochores control and adapt to major chromosomal transactions, including replication of centromeric DNA, biorientation of sister centromeres on the metaphase spindle, and transit of sister chromatids into daughter cells during anaphase. Although the mechanisms that ensure tight microtubule coupling at anaphase are at least partly understood, kinetochore adaptations that support other cell cycle transitions are not. We report here a mechanism that enables regulated control of kinetochore sumoylation. A conserved surface of the Ctf3/CENP-I kinetochore protein provides a binding site for Ulp2, the nuclear enzyme that removes SUMO chains from modified substrates. Ctf3 mutations that disable Ulp2 recruitment cause elevated inner kinetochore sumoylation and defective chromosome segregation. The location of the site within the assembled kinetochore suggests coordination between sumoylation and other cell cycle-regulated processes.
External linksJ Cell Biol / PubMed:34081091 / PubMed Central
MethodsEM (single particle)
Resolution3.7 Å
Structure data

23216

7l7q

EMDB-23216, PDB-7l7q:
Ctf3c with Ulp2-KIM
Method: EM (single particle) / Resolution: 3.7 Å

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsCELL CYCLE / kinetochore / sumo / DNA / chromosome segregation

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