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TitleA factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
Journal, issue, pagesBlood, Vol. 138, Page 1258-1268, Year 2021
Publish dateSep 25, 2020 (structure data deposition date)
AuthorsOstergaard, H. / Lund, J. / Greisen, P.J. / Kjellev, S. / Henriksen, A. / Lorenzen, N. / Johansson, E. / Roder, G. / Rasch, M.G. / Johnsen, L.B. ...Ostergaard, H. / Lund, J. / Greisen, P.J. / Kjellev, S. / Henriksen, A. / Lorenzen, N. / Johansson, E. / Roder, G. / Rasch, M.G. / Johnsen, L.B. / Egebjerg, T. / Lund, S. / Rahbek-Nielsen, H. / Gandhi, P.S. / Lamberth, K. / Loftager, M. / Andersen, L.M. / Bonde, A.C. / Stavenuiter, F. / Madsen, D.E. / Li, X. / Holm, T.L. / Ley, C.D. / Thygesen, P. / Zhu, H. / Zhou, R. / Thorn, K. / Yang, Z. / Hermit, M.B. / Bjelke, J.R. / Hansen, B.G. / Hilden, I.
External linksBlood / PubMed:34077951
MethodsX-ray diffraction
Resolution2.6 - 3.11 Å
Structure data

PDB-7ahu:
Anti-FX Fab of mim8 in complex with human FXa
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-7ahv:
Anti-FIXa Fab of mim8 in complex with human FIXa
Method: X-RAY DIFFRACTION / Resolution: 3.11 Å

Chemicals

ChemComp-0GJ:
L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsBLOOD CLOTTING / Fab / anti-FX / HYDROLASE / mim8 / anti-FIXa

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