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-Structure paper
Title | Acute pharmacological degradation of Helios destabilizes regulatory T cells. |
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Journal, issue, pages | Nat. Chem. Biol., Vol. 17, Page 711-717, Year 2021 |
Publish date | Feb 12, 2021 (structure data deposition date) |
![]() | Wang, E.S. / Verano, A.L. / Nowak, R.P. / Yuan, J.C. / Donovan, K.A. / Eleuteri, N.A. / Yue, H. / Ngo, K.H. / Lizotte, P.H. / Gokhale, P.C. ...Wang, E.S. / Verano, A.L. / Nowak, R.P. / Yuan, J.C. / Donovan, K.A. / Eleuteri, N.A. / Yue, H. / Ngo, K.H. / Lizotte, P.H. / Gokhale, P.C. / Gray, N.S. / Fischer, E.S. |
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Methods | X-ray diffraction |
Resolution | 3.78 Å |
Structure data | ![]() PDB-7lps: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-RN9: |
Source |
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![]() | LIGASE / CRBN / DDB1 / IKZF2 / ALV / Degradation / E3 ligase |