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TitleTargeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication.
Journal, issue, pagesCell Discov, Vol. 7, Page 37-37, Year 2021
Publish dateAug 22, 2020 (structure data deposition date)
AuthorsTu, W.J. / McCuaig, R.D. / Melino, M. / Rawle, D.J. / Le, T.T. / Yan, K. / Suhrbier, A. / Johnston, R.L. / Koufariotis, L.T. / Waddell, N. ...Tu, W.J. / McCuaig, R.D. / Melino, M. / Rawle, D.J. / Le, T.T. / Yan, K. / Suhrbier, A. / Johnston, R.L. / Koufariotis, L.T. / Waddell, N. / Cross, E.M. / Tsimbalyuk, S. / Bain, A. / Ahern, E. / Collinson, N. / Phipps, S. / Forwood, J.K. / Seddiki, N. / Rao, S.
External linksCell Discov / PubMed:34031383
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-7jvo:
Importin alpha bound to the C-terminus of ACE2
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / Importin / karyopherin / ACE2

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