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-Structure paper
タイトル | Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2. |
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ジャーナル・号・ページ | Commun Biol, Vol. 4, Issue 1, Page 606, Year 2021 |
掲載日 | 2021年5月21日 |
著者 | Isaac Fianu / Christian Dienemann / Shintaro Aibara / Sandra Schilbach / Patrick Cramer / |
PubMed 要旨 | Nuclear import of RNA polymerase II (Pol II) involves the conserved factor RPAP2. Here we report the cryo-electron microscopy (cryo-EM) structure of mammalian Pol II in complex with human RPAP2 at 2. ...Nuclear import of RNA polymerase II (Pol II) involves the conserved factor RPAP2. Here we report the cryo-electron microscopy (cryo-EM) structure of mammalian Pol II in complex with human RPAP2 at 2.8 Å resolution. The structure shows that RPAP2 binds between the jaw domains of the polymerase subunits RPB1 and RPB5. RPAP2 is incompatible with binding of downstream DNA during transcription and is displaced upon formation of a transcription pre-initiation complex. |
リンク | Commun Biol / PubMed:34021257 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 2.8 Å |
構造データ | EMDB-12087, PDB-7b7u: |
化合物 | ChemComp-ZN: |
由来 |
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キーワード | TRANSCRIPTION / RPAP2 / RNA polymerase II / Nuclear import |