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Structure paper

TitleNoncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 118, Year 2021
Publish dateMar 8, 2021 (structure data deposition date)
AuthorsJafari, N. / Del Rio, J. / Akimoto, M. / Byun, J.A. / Boulton, S. / Moleschi, K. / Alsayyed, Y. / Swanson, P. / Huang, J. / Martinez Pomier, K. ...Jafari, N. / Del Rio, J. / Akimoto, M. / Byun, J.A. / Boulton, S. / Moleschi, K. / Alsayyed, Y. / Swanson, P. / Huang, J. / Martinez Pomier, K. / Lee, C. / Wu, J. / Taylor, S.S. / Melacini, G.
External linksProc. Natl. Acad. Sci. USA / PubMed:34006641
MethodsX-ray diffraction
Resolution4.155 Å
Structure data

PDB-7lz4:
Crystal structure of A211D mutant of Protein Kinase A RIa subunit, a Carney Complex mutation
Method: X-RAY DIFFRACTION / Resolution: 4.155 Å

Chemicals

ChemComp-CMP:
ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE

Source
  • bos taurus (cattle)
KeywordsTRANSFERASE / Carney complex / cyclic nucleotide binding domain / cyclic AMP (cAMP) / protein kinase A (PKA)

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