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Title | A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 47, Page 128113-128113, Year 2021 |
Publish date | Jul 17, 2020 (structure data deposition date) |
Authors | Schulte, C.A. / Deaton, D.N. / Diaz, E. / Do, Y. / Gampe, R.T. / Guss, J.H. / Hancock, A.P. / Hobbs, H. / Hodgson, S.T. / Holt, J. ...Schulte, C.A. / Deaton, D.N. / Diaz, E. / Do, Y. / Gampe, R.T. / Guss, J.H. / Hancock, A.P. / Hobbs, H. / Hodgson, S.T. / Holt, J. / Jeune, M.R. / Kahler, K.M. / Kramer, H.F. / Le, J. / Mortenson, P.N. / Musetti, C. / Nolte, R.T. / Orband-Miller, L.A. / Peckham, G.E. / Petrov, K.G. / Pietrak, B.L. / Poole, C. / Price, D.J. / Saxty, G. / Shillings, A. / Smalley Jr., T.L. / Somers, D.O. / Stewart, E.L. / Stuart, J.D. / Thomson, S.A. |
External links | Bioorg. Med. Chem. Lett. / PubMed:33991628 |
Methods | X-ray diffraction |
Resolution | 1.13 - 1.88 Å |
Structure data | PDB-6ztc: PDB-7jr6: PDB-7jr8: |
Chemicals | ChemComp-GSH: ChemComp-MG: ChemComp-QPN: ChemComp-GOL: ChemComp-HOH: ChemComp-VH4: ChemComp-NA: ChemComp-CL: ChemComp-EDO: ChemComp-VH7: |
Source |
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Keywords | ISOMERASE / PROSTAGLANDIN BIOSYNTHESIS / FATTY ACID BIOSYNTHESIS / PROSTAGLANDIN D2 SYNTHASE / PGDS / ASTHMA / CYTOPLASM / LIPID SYNTHESIS / Transferase/Inhibitor / Hematopoietic prostaglandin D2 synthase / inhibitor / Transferase-Inhibitor complex |