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TitleStructure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions.
Journal, issue, pagesJ. Allergy Clin. Immunol., Vol. 148, Page 1049-1060, Year 2021
Publish dateMay 19, 2021 (structure data deposition date)
AuthorsPennington, L.F. / Gasser, P. / Brigger, D. / Guntern, P. / Eggel, A. / Jardetzky, T.S.
External linksJ. Allergy Clin. Immunol. / PubMed:33991582
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-7mxi:
IgE-Fc in complex with DARPins E2_79 and E3_53
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / IgE / DARPin / Allergy / Inhibitor

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