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-Structure paper
| Title | Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. |
|---|---|
| Journal, issue, pages | Nat Commun, Vol. 12, Page 2792-2792, Year 2021 |
| Publish date | May 14, 2020 (structure data deposition date) |
 Authors | Rogawski, D.S. / Deng, J. / Li, H. / Miao, H. / Borkin, D. / Purohit, T. / Song, J. / Chase, J. / Li, S. / Ndoj, J. ...Rogawski, D.S. / Deng, J. / Li, H. / Miao, H. / Borkin, D. / Purohit, T. / Song, J. / Chase, J. / Li, S. / Ndoj, J. / Klossowski, S. / Kim, E. / Mao, F. / Zhou, B. / Ropa, J. / Krotoska, M.Z. / Jin, Z. / Ernst, P. / Feng, X. / Huang, G. / Nishioka, K. / Kelly, S. / He, M. / Wen, B. / Sun, D. / Muntean, A. / Dou, Y. / Maillard, I. / Cierpicki, T. / Grembecka, J. |
 External links | Nat Commun / PubMed:33990599 |
| Methods | X-ray diffraction |
| Resolution | 1.69 Å |
| Structure data |  PDB-6wzw:  PDB-6x0p: |
| Chemicals |  ChemComp-EPE:  ChemComp-SAM:  ChemComp-ZN:  ChemComp-UG7:  ChemComp-HOH:  ChemComp-UK7: |
| Source |
|
 Keywords | PROTEIN BINDING / TRANSFERASE/INHIBITOR / Methyltransferase / complex / TRANSFERASE-INHIBITOR complex |
homo sapiens (human)