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Structure paper

TitleThe SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.
Journal, issue, pagesSci Adv, Vol. 7, Year 2021
Publish dateJan 29, 2020 (structure data deposition date)
AuthorsStielow, B. / Zhou, Y. / Cao, Y. / Simon, C. / Pogoda, H.M. / Jiang, J. / Ren, Y. / Phanor, S.K. / Rohner, I. / Nist, A. ...Stielow, B. / Zhou, Y. / Cao, Y. / Simon, C. / Pogoda, H.M. / Jiang, J. / Ren, Y. / Phanor, S.K. / Rohner, I. / Nist, A. / Stiewe, T. / Hammerschmidt, M. / Shi, Y. / Bulyk, M.L. / Wang, Z. / Liefke, R.
External linksSci Adv / PubMed:33980486
MethodsX-ray diffraction
Resolution1.12 - 2.054 Å
Structure data

PDB-6lui:
Crystal structure of the SAMD1 WH domain and DNA complex
Method: X-RAY DIFFRACTION / Resolution: 1.781 Å

PDB-6luj:
Crystal structure of the SAMD1 SAM domain
Method: X-RAY DIFFRACTION / Resolution: 1.12 Å

PDB-6luk:
Crystal structure of the SAMD1 SAM domain in another crystal form
Method: X-RAY DIFFRACTION / Resolution: 2.054 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / CpG islands; transcription; polycomb / CpG-islands / transcription / pentamer / decamer

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