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TitleSelective and noncovalent targeting of RAS mutants for inhibition and degradation.
Journal, issue, pagesNat Commun, Vol. 12, Page 2656-2656, Year 2021
Publish dateDec 11, 2020 (structure data deposition date)
AuthorsTeng, K.W. / Tsai, S.T. / Hattori, T. / Fedele, C. / Koide, A. / Yang, C. / Hou, X. / Zhang, Y. / Neel, B.G. / O'Bryan, J.P. / Koide, S.
External linksNat Commun / PubMed:33976200
MethodsX-ray diffraction
Resolution1.98 - 2.54 Å
Structure data

PDB-7l0f:
Monobody 12VC3 Bound to HRAS(WT)
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

PDB-7l0g:
Monobody 12VC1 Bound to HRAS(G12C)
Method: X-RAY DIFFRACTION / Resolution: 2.54 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GSP:
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / RAS GTPase

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