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-Structure paper
| Title | Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. |
|---|---|
| Journal, issue, pages | Nat. Chem. Biol., Vol. 17, Page 954-963, Year 2021 |
| Publish date | Dec 17, 2019 (structure data deposition date) |
 Authors | Dubiella, C. / Pinch, B.J. / Koikawa, K. / Zaidman, D. / Poon, E. / Manz, T.D. / Nabet, B. / He, S. / Resnick, E. / Rogel, A. ...Dubiella, C. / Pinch, B.J. / Koikawa, K. / Zaidman, D. / Poon, E. / Manz, T.D. / Nabet, B. / He, S. / Resnick, E. / Rogel, A. / Langer, E.M. / Daniel, C.J. / Seo, H.S. / Chen, Y. / Adelmant, G. / Sharifzadeh, S. / Ficarro, S.B. / Jamin, Y. / Martins da Costa, B. / Zimmerman, M.W. / Lian, X. / Kibe, S. / Kozono, S. / Doctor, Z.M. / Browne, C.M. / Yang, A. / Stoler-Barak, L. / Shah, R.B. / Vangos, N.E. / Geffken, E.A. / Oren, R. / Koide, E. / Sidi, S. / Shulman, Z. / Wang, C. / Marto, J.A. / Dhe-Paganon, S. / Look, T. / Zhou, X.Z. / Lu, K.P. / Sears, R.C. / Chesler, L. / Gray, N.S. / London, N. |
 External links | Nat. Chem. Biol. / PubMed:33972797 |
| Methods | X-ray diffraction |
| Resolution | 1.42 Å |
| Structure data |  PDB-6vaj: |
| Chemicals |  ChemComp-QT7:  ChemComp-SO4:  ChemComp-PG4:  ChemComp-HOH: |
| Source |
|
 Keywords | ISOMERASE/ISOMERASE INHIBITOR / PPIase / covalent inhibitor / ISOMERASE / ISOMERASE-ISOMERASE INHIBITOR complex |
homo sapiens (human)