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TitleARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma.
Journal, issue, pagesNature, Vol. 594, Page 418-423, Year 2021
Publish dateJun 16, 2020 (structure data deposition date)
AuthorsYen, I. / Shanahan, F. / Lee, J. / Hong, Y.S. / Shin, S.J. / Moore, A.R. / Sudhamsu, J. / Chang, M.T. / Bae, I. / Dela Cruz, D. ...Yen, I. / Shanahan, F. / Lee, J. / Hong, Y.S. / Shin, S.J. / Moore, A.R. / Sudhamsu, J. / Chang, M.T. / Bae, I. / Dela Cruz, D. / Hunsaker, T. / Klijn, C. / Liau, N.P.D. / Lin, E. / Martin, S.E. / Modrusan, Z. / Piskol, R. / Segal, E. / Venkatanarayan, A. / Ye, X. / Yin, J. / Zhang, L. / Kim, J.S. / Lim, H.S. / Kim, K.P. / Kim, Y.J. / Han, H.S. / Lee, S.J. / Kim, S.T. / Jung, M. / Hong, Y.H. / Noh, Y.S. / Choi, M. / Han, O. / Nowicka, M. / Srinivasan, S. / Yan, Y. / Kim, T.W. / Malek, S.
External linksNature / PubMed:33953400
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-6xfp:
Crystal Structure of BRAF kinase domain bound to Belvarafenib
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-V1Y:
4-amino-N-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide / antitumor, inhibitor*YM

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / BRAF Belvarafenib

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