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TitleStructural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations.
Journal, issue, pagesCancers (Basel), Vol. 13, Year 2021
Publish dateJul 30, 2020 (structure data deposition date)
AuthorsPozzi, C. / Santucci, M. / Marverti, G. / D'Arca, D. / Tagliazucchi, L. / Ferrari, S. / Gozzi, G. / Losi, L. / Tassone, G. / Mangani, S. ...Pozzi, C. / Santucci, M. / Marverti, G. / D'Arca, D. / Tagliazucchi, L. / Ferrari, S. / Gozzi, G. / Losi, L. / Tassone, G. / Mangani, S. / Ponterini, G. / Costi, M.P.
External linksCancers (Basel) / PubMed:33923290
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-6zxo:
Crystal structure of His-tagged human thymidylate synthase (HT-hTS) in complex with FdUMP and Raltitrexed (Tomudex)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-D16:
TOMUDEX / chemotherapy, inhibitor*YM

ChemComp-UFP:
5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE / inhibitor*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / human Thymidylate Synthase / hTS / active conformation / FdUMP / Ratitrexed / Tomudex / Methyltransferase / folate pathway

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