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TitleTumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.
Journal, issue, pagesCell Metab., Vol. 33, Page 1221-1233.e11, Year 2021
Publish dateJul 17, 2020 (structure data deposition date)
AuthorsLiu, Y. / Liang, G. / Xu, H. / Dong, W. / Dong, Z. / Qiu, Z. / Zhang, Z. / Li, F. / Huang, Y. / Li, Y. ...Liu, Y. / Liang, G. / Xu, H. / Dong, W. / Dong, Z. / Qiu, Z. / Zhang, Z. / Li, F. / Huang, Y. / Li, Y. / Wu, J. / Yin, S. / Zhang, Y. / Guo, P. / Liu, J. / Xi, J.J. / Jiang, P. / Han, D. / Yang, C.G. / Xu, M.M.
External linksCell Metab. / PubMed:33910046
MethodsX-ray diffraction
Resolution2.35 Å
Structure data

PDB-7ckk:
Structural complex of FTO bound with Dac51
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-OGA:
N-OXALYLGLYCINE / inhibitor*YM

ChemComp-B6C:
2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / Inhibitor / Complex / Demethylase

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