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TitleIncreased resistance of SARS-CoV-2 variant P.1 to antibody neutralization.
Journal, issue, pagesCell Host Microbe, Vol. 29, Issue 5, Page 747-751.e4, Year 2021
Publish dateMay 12, 2021
AuthorsPengfei Wang / Ryan G Casner / Manoj S Nair / Maple Wang / Jian Yu / Gabriele Cerutti / Lihong Liu / Peter D Kwong / Yaoxing Huang / Lawrence Shapiro / David D Ho /
PubMed AbstractThe emergence of SARS-CoV-2 variants has raised concerns about altered sensitivity to antibody-mediated immunity. The relative resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to antibody ...The emergence of SARS-CoV-2 variants has raised concerns about altered sensitivity to antibody-mediated immunity. The relative resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to antibody neutralization has been recently investigated. We report that another emergent variant from Brazil, P.1, is not only refractory to multiple neutralizing monoclonal antibodies but also more resistant to neutralization by convalescent plasma and vaccinee sera. The magnitude of resistance is greater for monoclonal antibodies than vaccinee sera and evident with both pseudovirus and authentic P.1 virus. The cryoelectron microscopy structure of a soluble prefusion-stabilized spike reveals that the P.1 trimer adopts exclusively a conformation in which one of the receptor-binding domains is in the "up" position, which is known to facilitate binding to entry receptor ACE2. The functional impact of P.1 mutations thus appears to arise from local changes instead of global conformational alterations. The P.1 variant threatens current antibody therapies but less so protective vaccine efficacy.
External linksCell Host Microbe / PubMed:33887205 / PubMed Central
MethodsEM (single particle)
Structure data

23718

7m8k

EMDB-23718, PDB-7m8k:
Cryo-EM structure of Brazil (P.1) SARS-CoV-2 spike glycoprotein variant in the prefusion state (1 RBD up)
Method: EM (single particle)

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / Spike Glycoprotein

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