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-Structure paper
タイトル | The "Jack-of-all-Trades" Flagellum From and Was Horizontally Acquired From an Ancestral β-Proteobacterium. |
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ジャーナル・号・ページ | Front Microbiol, Vol. 12, Page 643180, Year 2021 |
掲載日 | 2021年3月30日 |
著者 | Josie L Ferreira / Izaak Coleman / Max L Addison / Tobias Zachs / Bonnie L Quigley / Kristin Wuichet / Morgan Beeby / |
PubMed 要旨 | The γ-proteobacteria are a group of diverse bacteria including pathogenic , and species. The majority swim in liquids with polar, sodium-driven flagella and swarm on surfaces with lateral, non- ...The γ-proteobacteria are a group of diverse bacteria including pathogenic , and species. The majority swim in liquids with polar, sodium-driven flagella and swarm on surfaces with lateral, non-chemotactic flagella. Notable exceptions are the enteric Enterobacteriaceae such as and . Many of the well-studied Enterobacteriaceae are gut bacteria that both swim and swarm with the same proton-driven peritrichous flagella. How different flagella evolved in closely related lineages, however, has remained unclear. Here, we describe our phylogenetic finding that Enterobacteriaceae flagella are not native polar or lateral γ-proteobacterial flagella but were horizontally acquired from an ancestral β-proteobacterium. Using electron cryo-tomography and subtomogram averaging, we confirmed that Enterobacteriaceae flagellar motors resemble contemporary β-proteobacterial motors and are distinct to the polar and lateral motors of other γ-proteobacteria. Structural comparisons support a model in which γ-proteobacterial motors have specialized, suggesting that acquisition of a β-proteobacterial flagellum may have been beneficial as a general-purpose motor suitable for adjusting to diverse conditions. This acquisition may have played a role in the development of the enteric lifestyle. |
リンク | Front Microbiol / PubMed:33859630 / PubMed Central |
手法 | EM (サブトモグラム平均) |
解像度 | 83.0 - 120.0 Å |
構造データ | EMDB-10000: EMDB-4999: |
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