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-Structure paper
タイトル | Synthesis of the Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor NB-360. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 64, Page 4677-4696, Year 2021 |
掲載日 | 2020年11月24日 (構造データの登録日) |
![]() | Rueeger, H. / Lueoend, R. / Machauer, R. / Veenstra, S.J. / Holzer, P. / Hurth, K. / Voegtle, M. / Frederiksen, M. / Rondeau, J.M. / Tintelnot-Blomley, M. ...Rueeger, H. / Lueoend, R. / Machauer, R. / Veenstra, S.J. / Holzer, P. / Hurth, K. / Voegtle, M. / Frederiksen, M. / Rondeau, J.M. / Tintelnot-Blomley, M. / Jacobson, L.H. / Staufenbiel, M. / Laue, G. / Neumann, U. |
![]() | ![]() ![]() |
手法 | X線回折 |
解像度 | 1.62 - 1.94 Å |
構造データ | ![]() PDB-7b1e: ![]() PDB-7b1p: ![]() PDB-7b1q: |
化合物 | ![]() ChemComp-SKW: ![]() ChemComp-HOH: ![]() ChemComp-SL8: ![]() ChemComp-SLK: |
由来 |
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![]() | HYDROLASE / Beta-secretase; BACE1; memapsin2; Aspartic acid proteinase; alzheimer's disease; enzyme inhibitor complex; Structure-based drug design / Beta-secretase; BACE1; memapsin2; Aspartic proteinase; alzheimer's disease; enzyme-inhibitor complex; Structure-based drug design / Beta-secretase; BACE1; memaosin2; aspartic acid proteinase; alzheimer's disease; enzyme-inhibitor complex; Structure-based drug design |