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TitleDiscovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET.
Journal, issue, pagesJ. Biol. Chem., Vol. 296, Page 100641-100641, Year 2021
Publish dateMay 7, 2020 (structure data deposition date)
AuthorsNeijssen, J. / Cardoso, R.M.F. / Chevalier, K.M. / Wiegman, L. / Valerius, T. / Anderson, G.M. / Moores, S.L. / Schuurman, J. / Parren, P.W.H.I. / Strohl, W.R. / Chiu, M.L.
External linksJ. Biol. Chem. / PubMed:33839159
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-6wvz:
Crystal structure of anti-MET Fab arm of amivantamab in complex with human MET
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Immune System / ANTIGEN-FAB COMPLEX / SEMAPHORIN DOMAIN / PLEXIN SEMAPHORIN INTEGRIN CYSTEINE-RICH DOMAIN / ANTITUMOR PROTEIN / Transferase-Immune System complex

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