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-Structure paper
Title | Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 4709-4729, Year 2021 |
Publish date | Aug 14, 2020 (structure data deposition date) |
Authors | Yu, W. / Liu, J. / Clausen, D. / Yu, Y. / Duffy, J.L. / Wang, M. / Xu, S. / Deng, L. / Suzuki, T. / Chung, C.C. ...Yu, W. / Liu, J. / Clausen, D. / Yu, Y. / Duffy, J.L. / Wang, M. / Xu, S. / Deng, L. / Suzuki, T. / Chung, C.C. / Myers, R.W. / Klein, D.J. / Fells, J.I. / Holloway, M.K. / Wu, J. / Wu, G. / Howell, B.J. / Barnard, R.J.O. / Kozlowski, J. |
External links | J. Med. Chem. / PubMed:33797924 |
Methods | X-ray diffraction |
Resolution | 1.634 Å |
Structure data | PDB-7js8: |
Chemicals | ChemComp-ZN: ChemComp-SO4: ChemComp-CA: ChemComp-PEG: ChemComp-VJV: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / HISTONE DEACETYLASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEX |