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TitleEffective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo.
Journal, issue, pagesSci Rep, Vol. 11, Page 7358-7358, Year 2021
Publish dateJul 24, 2020 (structure data deposition date)
AuthorsPeplau, E. / De Rose, F. / Eichinger, A. / Reder, S. / Mittelhauser, M. / Scafetta, G. / Schwaiger, M. / Weber, W.A. / Bartolazzi, A. / D'Alessandria, C. / Skerra, A.
External linksSci Rep / PubMed:33795750
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-6zvf:
Crystal structure of the recombinant Fab fragment derived from the hybridoma M3/38 in complex with a human Galectin-3 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / ANTIBODY / FAB FRAGMENT / PEPTIDE EPITOPE / PROTEIN ENGINEERING

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