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TitleBicyclic beta-Sheet Mimetics that Target the Transcriptional Coactivator beta-Catenin and Inhibit Wnt Signaling.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 60, Page 13937-13944, Year 2021
Publish dateOct 23, 2020 (structure data deposition date)
AuthorsWendt, M. / Bellavita, R. / Gerber, A. / Efrem, N.L. / van Ramshorst, T. / Pearce, N.M. / Davey, P.R.J. / Everard, I. / Vazquez-Chantada, M. / Chiarparin, E. ...Wendt, M. / Bellavita, R. / Gerber, A. / Efrem, N.L. / van Ramshorst, T. / Pearce, N.M. / Davey, P.R.J. / Everard, I. / Vazquez-Chantada, M. / Chiarparin, E. / Grieco, P. / Hennig, S. / Grossmann, T.N.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:33783110
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-7ar4:
Crystal structure of beta-catenin in complex with cyclic peptide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsSIGNALING PROTEIN / Wnt signaling / Peptide Inhibitor / Protein-Peptide Interaction

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