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-Structure paper
Title | Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central A beta reduction. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 216, Page 113270-113270, Year 2021 |
Publish date | Sep 18, 2020 (structure data deposition date) |
![]() | Nakahara, K. / Mitsuoka, Y. / Kasuya, S. / Yamamoto, T. / Yamamoto, S. / Ito, H. / Kido, Y. / Kusakabe, K.I. |
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Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | ![]() PDB-7d36: |
Chemicals | ![]() ChemComp-IOD: ![]() ChemComp-GOL: ![]() ChemComp-GUC: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / BACE1 |