Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Quadrivalent influenza nanoparticle vaccines induce broad protection.
Journal, issue, pages	Nature, Vol. 592, Issue 7855, Page 623-628, Year 2021
Publish date	Mar 24, 2021
Authors	Seyhan Boyoglu-Barnum / Daniel Ellis / Rebecca A Gillespie / Geoffrey B Hutchinson / Young-Jun Park / Syed M Moin / Oliver J Acton / Rashmi Ravichandran / Mike Murphy / Deleah Pettie / Nick Matheson / Lauren Carter / Adrian Creanga / Michael J Watson / Sally Kephart / Sila Ataca / John R Vaile / George Ueda / Michelle C Crank / Lance Stewart / Kelly K Lee / Miklos Guttman / David Baker / John R Mascola / David Veesler / Barney S Graham / Neil P King / Masaru Kanekiyo /
PubMed Abstract	Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation ...Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation and immunization. Here we show that computationally designed, two-component nanoparticle immunogens induce potently neutralizing and broadly protective antibody responses against a wide variety of influenza viruses. The nanoparticle immunogens contain 20 haemagglutinin glycoprotein trimers in an ordered array, and their assembly in vitro enables the precisely controlled co-display of multiple distinct haemagglutinin proteins in defined ratios. Nanoparticle immunogens that co-display the four haemagglutinins of licensed quadrivalent influenza vaccines elicited antibody responses in several animal models against vaccine-matched strains that were equivalent to or better than commercial quadrivalent influenza vaccines, and simultaneously induced broadly protective antibody responses to heterologous viruses by targeting the subdominant yet conserved haemagglutinin stem. The combination of potent receptor-blocking and cross-reactive stem-directed antibodies induced by the nanoparticle immunogens makes them attractive candidates for a supraseasonal influenza vaccine candidate with the potential to replace conventional seasonal vaccines.
External links	Nature / PubMed:33762730 / PubMed Central
Methods	EM (single particle)
Resolution	3.3 - 6.6 Å
Structure data	EMDB-22935: Elicitation of broadly protective immunity to influenza viruses by multivalent hemagglutinin nanoparticle vaccines Method: EM (single particle) / Resolution: 6.6 Å 22937 7kna EMDB-22937, PDB-7kna: Localized reconstruction of the H1 A/Michigan/45/2015 ectodomain displayed at the surface of I53_dn5 nanoparticle Method: EM (single particle) / Resolution: 3.3 Å EMDB-22938: H5 hemagglutinin ectodomain bound to 1 polyclonal Fab fragment elicited by the qsMosaic-I53_dn5 immunogen Method: EM (single particle) / Resolution: 4.0 Å EMDB-22939: H5 hemagglutinin ectodomain bound to 2 polyclonal Fab fragments elicited by the qsMosaic-I53_dn5 immunogen Method: EM (single particle) / Resolution: 4.1 Å EMDB-22940: H5 hemagglutinin ectodomain bound to 3 polyclonal Fab fragments elicited by the qsMosaic-I53_dn5 immunogen Method: EM (single particle) / Resolution: 3.6 Å
Chemicals	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine
Source	influenza virus influenza a virus synthetic construct (others) unidentified influenza virus Macaca mulatta (Rhesus monkey)
Keywords	VIRAL PROTEIN / hemagglutinin / fusion protein / neutralizing antibodies / vaccine / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / SSGCID