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Structure paper

TitleStructural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2.
Journal, issue, pagesCell Res, Vol. 31, Issue 6, Page 717-719, Year 2021
Publish dateMar 18, 2021
AuthorsRenhong Yan / Yuanyuan Zhang / Yaning Li / Fangfei Ye / Yingying Guo / Lu Xia / Xinyue Zhong / Ximin Chi / Qiang Zhou /
External linksCell Res / PubMed:33737693 / PubMed Central
MethodsEM (single particle)
Resolution2.7 - 10.4 Å
Structure data

EMDB-30888, PDB-7dwx:
Conformation 1 of S-ACE2-B0AT1 ternary complex
Method: EM (single particle) / Resolution: 8.3 Å

EMDB-30889, PDB-7dwy:
S protein of SARS-CoV-2 in the locked conformation
Method: EM (single particle) / Resolution: 2.7 Å

EMDB-30890, PDB-7dwz:
S protein of SARS-CoV-2 in the active conformation
Method: EM (single particle) / Resolution: 3.3 Å

EMDB-30891, PDB-7dx0:
Trypsin-digested S protein of SARS-CoV-2
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-30892, PDB-7dx1:
S protein of SARS-CoV-2 D614G mutant
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-30893, PDB-7dx2:
Trypsin-digested S protein of SARS-CoV-2 D614G mutant
Method: EM (single particle) / Resolution: 3.3 Å

EMDB-30894, PDB-7dx3:
S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 1 (1 up RBD and no PD bound)
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-30896, PDB-7dx5:
S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 2 (1 up RBD and 1 PD bound)
Method: EM (single particle) / Resolution: 3.3 Å

EMDB-30897, PDB-7dx6:
S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 3 (2 up RBD and 1 PD bound)
Method: EM (single particle) / Resolution: 3.0 Å

EMDB-30898, PDB-7dx7:
Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 1 (1 up RBD and 1 PD bound)
Method: EM (single particle) / Resolution: 3.4 Å

EMDB-30899, PDB-7dx8:
Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 2 (2 up RBD and 2 PD bound)
Method: EM (single particle) / Resolution: 2.9 Å

EMDB-30900, PDB-7dx9:
Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 3 (3 up RBD and 2 PD bound)
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-30965:
Cryo-EM map of the conformation 1 of S-ACE2-B0AT1 ternary complex focused right SARS-CoV-2
Method: EM (single particle) / Resolution: 6.7 Å

EMDB-30966:
Cryo-EM map of the conformation 1 of S-ACE2-B0AT1 ternary complex focused left SARS-CoV-2
Method: EM (single particle) / Resolution: 10.4 Å

EMDB-30967:
Cryo-EM map of the conformation 2 of S-ACE2-B0AT1 ternary complex focused ACE2-B0AT1 complex
Method: EM (single particle) / Resolution: 8.4 Å

EMDB-30968:
Cryo-EM map of the conformation 2 of S-ACE2-B0AT1 ternary complex
Method: EM (single particle) / Resolution: 4.4 Å

EMDB-30969:
Cryo-EM map of the conformation 2 of S-ACE2-B0AT1 ternary complex focused S protein
Method: EM (single particle) / Resolution: 4.3 Å

EMDB-30970:
Cryo-EM map of the conformation 2 of S-ACE2-B0AT1 ternary complex focused ACE2-B0AT1 complex
Method: EM (single particle) / Resolution: 4.4 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

ChemComp-LEU:
LEUCINE / Leucine

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER / Water

ChemComp-EIC:
LINOLEIC ACID / Linoleic acid

Source
  • homo sapiens (human)
  • severe acute respiratory syndrome coronavirus 2
  • Homo sapien (human)
KeywordsVIRUS / SARS-CoV-2

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