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-Structure paper
タイトル | Ccdc113/Ccdc96 complex, a novel regulator of ciliary beating that connects radial spoke 3 to dynein g and the nexin link. |
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ジャーナル・号・ページ | PLoS Genet, Vol. 17, Issue 3, Page e1009388, Year 2021 |
掲載日 | 2021年3月4日 |
著者 | Rafał Bazan / Adam Schröfel / Ewa Joachimiak / Martyna Poprzeczko / Gaia Pigino / Dorota Wloga / |
PubMed 要旨 | Ciliary beating requires the coordinated activity of numerous axonemal complexes. The protein composition and role of radial spokes (RS), nexin links (N-DRC) and dyneins (ODAs and IDAs) is well ...Ciliary beating requires the coordinated activity of numerous axonemal complexes. The protein composition and role of radial spokes (RS), nexin links (N-DRC) and dyneins (ODAs and IDAs) is well established. However, how information is transmitted from the central apparatus to the RS and across other ciliary structures remains unclear. Here, we identify a complex comprising the evolutionarily conserved proteins Ccdc96 and Ccdc113, positioned parallel to N-DRC and forming a connection between RS3, dynein g, and N-DRC. Although Ccdc96 and Ccdc113 can be transported to cilia independently, their stable docking and function requires the presence of both proteins. Deletion of either CCDC113 or CCDC96 alters cilia beating frequency, amplitude and waveform. We propose that the Ccdc113/Ccdc96 complex transmits signals from RS3 and N-DRC to dynein g and thus regulates its activity and the ciliary beat pattern. |
リンク | PLoS Genet / PubMed:33661892 / PubMed Central |
手法 | EM (サブトモグラム平均) |
解像度 | 34.0 - 35.0 Å |
構造データ | EMDB-12119: EMDB-12120: EMDB-12121: |
由来 |
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