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TitleMechanism and Inhibition of Human Methionine Adenosyltransferase 2A.
Journal, issue, pagesBiochemistry, Vol. 60, Page 791-801, Year 2021
Publish dateDec 14, 2020 (structure data deposition date)
AuthorsNiland, C.N. / Ghosh, A. / Cahill, S.M. / Schramm, V.L.
External linksBiochemistry / PubMed:33656855
MethodsX-ray diffraction
Resolution1.25 Å
Structure data

PDB-7l1a:
Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor, di-imido triphosphate (PNPNP)
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-XE1:
N,N'-(dihydroxy-lambda~5~-phosphanediyl)bis(phosphoramidic acid)

ChemComp-MTA:
5'-DEOXY-5'-METHYLTHIOADENOSINE

ChemComp-ALA:
ALANINE

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/INHIBITOR / S-adenosylmethionine / SAM synthetase / enzyme mechanism / inhibitor / TRANSFERASE-INHIBITOR complex

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