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TitleCD25-T reg -depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity.
Journal, issue, pagesNat Cancer, Vol. 1, Page 1153-1166, Year 2020
Publish dateApr 1, 2020 (structure data deposition date)
AuthorsSolomon, I. / Amann, M. / Goubier, A. / Vargas, F.A. / Zervas, D. / Qing, C. / Henry, J.Y. / Ghorani, E. / Akarca, A.U. / Marafioti, T. ...Solomon, I. / Amann, M. / Goubier, A. / Vargas, F.A. / Zervas, D. / Qing, C. / Henry, J.Y. / Ghorani, E. / Akarca, A.U. / Marafioti, T. / Sledzinska, A. / Sunderland, M.W. / Demane, D.F. / Clancy, J.R. / Georgiou, A. / Salimu, J. / Merchiers, P. / Brown, M.A. / Flury, R. / Eckmann, J. / Murgia, C. / Sam, J. / Jacobsen, B. / Marrer-Berger, E. / Boetsch, C. / Belli, S. / Leibrock, L. / Benz, J. / Koll, H. / Sutmuller, R. / Peggs, K.S. / Quezada, S.A.
External linksNat Cancer / PubMed:33644766
MethodsX-ray diffraction
Resolution1.83 Å
Structure data

PDB-6yio:
CRYSTAL STRUCTURE OF FAB RG6292 IN COMPLEX WITH CD25 ECD
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / ANTIBODY / CD25 ECD / FAB RG6292 / IL2Ra

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