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TitleDiscovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle.
Journal, issue, pagesJ. Virol., Vol. 95, Year 2021
Publish dateDec 29, 2018 (structure data deposition date)
AuthorsYang, F. / Pang, B. / Lai, K.K. / Cheung, N.N. / Dai, J. / Zhang, W. / Zhang, J. / Chan, K.H. / Chen, H. / Sze, K.H. ...Yang, F. / Pang, B. / Lai, K.K. / Cheung, N.N. / Dai, J. / Zhang, W. / Zhang, J. / Chan, K.H. / Chen, H. / Sze, K.H. / Zhang, H. / Hao, Q. / Yang, D. / Yuen, K.Y. / Kao, R.Y.
External linksJ. Virol. / PubMed:33627391
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-6j1u:
influenza virus nucleoprotein with a specific inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-B7O:
~{N}-[4-[(4-~{tert}-butylphenyl)carbonylamino]phenyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide

Source
  • influenza a virus (strain a/wilson-smith/1933 h1n1)
KeywordsVIRAL PROTEIN / inhibitor / complex / influenza / H1N1

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