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TitleSLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function.
Journal, issue, pagesJ. Mol. Biol., Vol. 433, Page 166880-166880, Year 2021
Publish dateJun 4, 2020 (structure data deposition date)
AuthorsWybenga-Groot, L.E. / Tench, A.J. / Simpson, C.D. / Germain, J.S. / Raught, B. / Moran, M.F. / McGlade, C.J.
External linksJ. Mol. Biol. / PubMed:33617900
MethodsX-ray diffraction
Resolution2.501 Å
Structure data

PDB-6xar:
Structure of CBL tyrosine kinase binding domain (TKBD) with C-terminal tail of Src-like kinase protein 2 (SLAP2)
Method: X-RAY DIFFRACTION / Resolution: 2.501 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsSIGNALING PROTEIN / adaptor / E3 ubiquitin ligase / activation / complex

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