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Title | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model. |
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Journal, issue, pages | Science, Vol. 371, Page 1374-1378, Year 2021 |
Publish date | May 26, 2020 (structure data deposition date) |
Authors | Qiao, J. / Li, Y.S. / Zeng, R. / Liu, F.L. / Luo, R.H. / Huang, C. / Wang, Y.F. / Zhang, J. / Quan, B. / Shen, C. ...Qiao, J. / Li, Y.S. / Zeng, R. / Liu, F.L. / Luo, R.H. / Huang, C. / Wang, Y.F. / Zhang, J. / Quan, B. / Shen, C. / Mao, X. / Liu, X. / Sun, W. / Yang, W. / Ni, X. / Wang, K. / Xu, L. / Duan, Z.L. / Zou, Q.C. / Zhang, H.L. / Qu, W. / Long, Y.H. / Li, M.H. / Yang, R.C. / You, J. / Zhou, Y. / Yao, R. / Li, W.P. / Liu, J.M. / Chen, P. / Liu, Y. / Lin, G.F. / Yang, X. / Zou, J. / Li, L. / Hu, Y. / Lu, G.W. / Li, W.M. / Wei, Y.Q. / Zheng, Y.T. / Lei, J. / Yang, S. |
External links | Science / PubMed:33602867 |
Methods | X-ray diffraction |
Resolution | 1.74 - 2.25 Å |
Structure data | PDB-7c7p: PDB-7com: PDB-7d3i: |
Chemicals | ChemComp-SV6: ChemComp-CL: ChemComp-HOH: ChemComp-U5G: ChemComp-GQU: ChemComp-TRS: |
Source |
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Keywords | VIRAL PROTEIN / coronavirus / protease / inhibitor / complex. / complex / viral protein. |