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-Structure paper
Title | Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 2691-2704, Year 2021 |
Publish date | Aug 6, 2020 (structure data deposition date) |
![]() | Olaoye, O.O. / Watson, P.R. / Nawar, N. / Geletu, M. / Sedighi, A. / Bukhari, S. / Raouf, Y.S. / Manaswiyoungkul, P. / Erdogan, F. / Abdeldayem, A. ...Olaoye, O.O. / Watson, P.R. / Nawar, N. / Geletu, M. / Sedighi, A. / Bukhari, S. / Raouf, Y.S. / Manaswiyoungkul, P. / Erdogan, F. / Abdeldayem, A. / Cabral, A.D. / Hassan, M.M. / Toutah, K. / Shouksmith, A.E. / Gawel, J.M. / Israelian, J. / Radu, T.B. / Kachhiyapatel, N. / de Araujo, E.D. / Christianson, D.W. / Gunning, P.T. |
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Methods | X-ray diffraction |
Resolution | 1.84 Å |
Structure data | ![]() PDB-7jom: |
Chemicals | ![]() ChemComp-TO3: ![]() ChemComp-EDO: ![]() ChemComp-FMT: ![]() ChemComp-ZN: ![]() ChemComp-K: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / Hydrolase / histone deacetylase / inhibitor / metallohydrolase / hydrolase-hydrolase inhibitor complex |