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-Structure paper
タイトル | Ribosome hibernation: a new molecular framework for targeting nonreplicating persisters of mycobacteria. |
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ジャーナル・号・ページ | Microbiology (Reading), Vol. 167, Issue 2, Year 2021 |
掲載日 | 2021年8月26日 |
著者 | Yunlong Li / Manjuli R Sharma / Ravi K Koripella / Nilesh K Banavali / Rajendra K Agrawal / Anil K Ojha / |
PubMed 要旨 | Treatment of tuberculosis requires a multi-drug regimen administered for at least 6 months. The long-term chemotherapy is attributed in part to a minor subpopulation of nonreplicating cells that ...Treatment of tuberculosis requires a multi-drug regimen administered for at least 6 months. The long-term chemotherapy is attributed in part to a minor subpopulation of nonreplicating cells that exhibit phenotypic tolerance to antibiotics. The origins of these cells in infected hosts remain unclear. Here we discuss some recent evidence supporting the hypothesis that hibernation of ribosomes in induced by zinc starvation, could be one of the primary mechanisms driving the development of nonreplicating persisters in hosts. We further analyse inconsistencies in previously reported studies to clarify the molecular principles underlying mycobacterial ribosome hibernation. |
リンク | Microbiology (Reading) / PubMed:33555244 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.1 Å |
構造データ | EMDB-23076: |
由来 |
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